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Home - Products - GPCR/G Protein - Calcium Channel - NNC 55-0396

NNC 55-0396

CAS No. 357400-13-6

NNC 55-0396( NNC 55-0396 dihydrochloride )

Catalog No. M14227 CAS No. 357400-13-6

A potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NNC 55-0396
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM.
  • Description
    A potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM; has no detectable effect on high-voltage-activated channels in INS-1 cells; inhibits MCF-7 (ERalpha+) cellular proliferation, inhibits tumor-induced angiogenesis in vitro and in vivo by suppressing HIF-1α stability; significantly suppresses glioblastoma tumor growth in a xenograft model.
  • In Vitro
    ——
  • In Vivo
    Animal Model:GABAA receptor α1 subunit null mouse model Dosage:20 mg/kg Administration:Intraperitoneal injection; 20 mg/kg, once Result:Suppressed tremor in GABAA subunit α1-null mice.
  • Synonyms
    NNC 55-0396 dihydrochloride
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    357400-13-6
  • Formula Weight
    564.5619
  • Molecular Formula
    C30H40Cl2FN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO
  • SMILES
    CC(C)C1C2=C(CCC1(CCN(C)CCCC3=NC4=CC=CC=C4N3)OC(=O)C5CC5)C=C(C=C2)F.Cl.Cl
  • Chemical Name
    Cyclopropanecarboxylic acid, (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, hydrochloride (1:2)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Huang L, et al. J Pharmacol Exp Ther. 2004 Apr;309(1):193-9. 2. Taylor JT, et al. Cancer Lett. 2008 Aug 18;267(1):116-24. 3. Kim KH, et al. J Mol Med (Berl). 2015 May;93(5):499-509.
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